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Across the 1980s and 1990s, GHK-Cu was studied extensively in wound healing applications, where it consistently demonstrated the ability to accelerate skin repair, stimulate collagen and glycosaminoglycan synthesis, and reduce inflammation at the site of injury

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While early, smaller trials showed promise by reducing infarct size (Piot et al., 2008), the larger CIRCUS trial subsequently failed to demonstrate improved clinical outcomes (Cung et al., 2015)

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