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If your weight loss progress stalls or reverses despite no changes in diet or exercise, suspect the medication before blaming your metabolism

Under diabetic conditions, hyperglycemia mediated reactive oxygen species (ROS) production and advanced glycation end products (AGEs) accumulation cause DNA damage, which subsequently promotes senescence of renal TECs and glomerular cells (11)

Those legal challenges forced the FDA to schedule public advisory committee meetings before taking further action

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Even when late-stage data look strong, the FDA still reviews efficacy, adverse events, manufacturing, labeling, contraindications, drug interactions, and risk-management requirements