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Classical enzymes controlled by NRF2, such as SOD, CAT, and heme oxygenase-1 (HO-1), are localized in various organelles and subcellular locations, where they actively scavenge ROS and neutralize electrophiles (Cuadrado et al

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It was used extensively in the 1990s to treat ADHD and is now the most common psychotropic medication prescribed to children in the United States and Australia to treat restlessness, impulsive behaviour and inattentiveness

Further research is needed to expand the current knowledge and employ more advanced literature synthesis techniques such as meta-analyses