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Within weeks, she reported clearer thinking, reduced pain, and improved daily function a typical response for chronic infections and toxic load conditions

Opiates such as morphine reliably inhibit the behavioral, electrophysiological and biochemical responses evoked by acute thermal, mechanical and other noxious stimuli in rats

In addition to participating in ubiquitin-dependent mitophagy, some mitochondrial proteins also act as mitophagy receptors, directly mediating the targeted binding and degradation process of dysfunctional mitochondria to autophagosomes (Figure 2f) (Table 1)

doi: 10.1186/s13063-018-3076-7 62 RechJTascilarKHagenMKleyerAMangerBSchoenauVet al

98 Caffeine is an adenosine receptor antagonist, and epidemiological studies have shown that the intake of caffeine is closely related to the occurrence of suicide 99 and depression