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Long-term insomnia is not only a risk factor for the incidence of T2DM [6] but also worsens glycemic control [7] and increases the risk of dementia [8], depression [9], and cardiovascular diseases such as hypertension, myocardial infarction, and stroke in T2DM [10]

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Methylation does not increase hydrophilicity because methyl group is lipophilic

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