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1 H NMR (300 MHz, DMSO) 8.23 (d, J = 7.4 Hz, 1H), 8.12 (d, J = 8.2 Hz, 1H), 7.41 (d, J = 6.6 Hz, 9H), 7.23 (s, 1H), 7.12 7.04 (m, 6H), 6.78 (d, J = 5.4 Hz, 1H), 6.67 (d, J = 11.0 Hz, 1H), 4.56 (d, J = 6.6 Hz, 1H), 4.14 (q, J = 7.4 Hz, 1H), 3.60 (s, 3H), 3.51 (d, J = 8.0 Hz, 2H), 2.78 (dq, J = 32.2, 7.5 Hz, 4H), 1.36 (d, J = 2.4 Hz, 24H)

A 70 kg adult in Schneider-Helmerts protocol received approximately 1,485 mcg intravenously

Simultaneous inhibition of CXCR1/2, TGF-beta, and PD-L1 remodels the tumor and its microenvironment to drive antitumor immunity

Kokate TG, Banks MK, Magee T, Yamaguchi S, Rogawski MA

However, manufacturing or using bacteriostatic water requires rigorous chemical and microbiological validation