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80 These protein complexes play an important role in fibroblast activation in the kidney, and their inhibition reduces or prevents the progression of CKD

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While many of those results may be attributed to GSH depletion, the contribution of GCLC to -glutamyl peptide synthesis and glutamate scavenging may also play a very important role, particularly in the context of xCT inhibition, where cells cannot export glutamate

Additionally, through subcellular fractionation and Western blot analysis, we detected a significant increase in the nuclear level of PARP-1 upon SRY overexpression in HepG2-SRY cells and Sry -TG mouse hepatocytes (Fig

After the ninhydrin test had indicated complete coupling, the mixture was filtered, and the peptidyl resin was washed three times with DMF