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In addition, PEM may be aggravated by problems in muscle repair

285 In the absence of oxidative modifications, this binding capability is absent, suggesting that redox modifications can specifically regulate the initiation of biological activities

They hydrolyze glutamine through enzymes such as phosphate-dependent GLS [24]

Other opioid-induced effects may include a reduction in biliary and pancreatic secretions, spasm of sphincter of Oddi, transient elevations in serum amylase, and opioid-induced esophageal dysfunction (OIED)