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Instead of being converted to IMP, the AMP builds up in the cells of affected individuals, spills into the blood, and is eventually metabolized in the liver

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When DNA damage is severe, hyperactivation of PARP-1 can be observed with consequent accumulation of poly (ADP-ribose) (PAR), and consumption of high amounts of NAD+

Manifestation Code as Principal Diagnosis Edit In the ICD-10-CM classification system, manifestation codes describe the manifestation of an underlying disease, not the disease itself, and therefore should not be used as a principal diagnosis