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Some ethnicities, such as Asian and south east Asians, can have hereditary hyperpigmentation and some individuals have a family history of puffy lower eyelids from fat prolapse, explains Dr Maryam Zamani, an oculoplastic surgeon and creator of MZ Skin

This could result in a failure to identify the treatment effect, or the impact of the treatment on the population

If you have concerns about your liver health or suspect liver-related issues, it's advisable to consult with a healthcare professional who can assess your liver function, evaluate B12 levels, and provide appropriate guidance

Mittag et al., 2010