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The context-dependent nature of Ta1 effects means it could behave differently in atopic tissue than predicted from other clinical settings

doi: 10.1007/s12020-012-9789-6 52 OlivieriBBetterleCZanoniG

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The established electrostatic interactions between residues Glu1581 and Gln1355 in the FAT domain and between residues Arg1585 of the FAT domain and Glu2311 of the C-lobe in the fully active state indicate direct communication between the FAT domain and the kinase domain to promote the active state (Fig