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Acknowledgements This work was supported by NIH grants R01Al111940, R01AI134810, R21A127182 and a Bill and Melinda Gates Foundation Award (OPP1130017) (A.J.C.S.), R01HL092857 (S.M.B.), P30DK079626 (UAB DRC BARB Core) and T32HL007918 (A.S.), by pilot funds from the UAB CFAR, CFRB and Infectious Diseases and Global Health and Vaccines Initiative, and the CRDF Global to A.J.C.S