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ROS generation and antioxidant defense systems in normal and Malignant cells

Cyclosporines rapid onset of action makes it an effective bridge therapy for patients transitioning to slower-acting systemic treatments, in transition strategies between different regimens, and during exacerbations (Singh & Argez 2018

doi: 10.1523/JNEUROSCI.15-10-06552.1995 243 GuoJIkedaSR

10.1074/jbc.M110.143685

In one study using the EAE model, invesigators demonstrated that SF (282 mol/kg/day for 14 days before EAE induction and 28 days after EAE induction) had anti-inflammatory effects, improved clinical scores in behavioral study, and inhibited demyelination in the spinal cords (92)