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The expression of VEGF mRNA is further upregulated when there is an increase in HIF-1, which increases during periods of hypoxia or injury

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The GLP-1 pathway also connects to broader hormonal systems that researchers studying pancreatic peptide hormones will recognize

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The World Health Organization (WHO) recognizes the use of acupuncture in the treatment of a wide range of common illnesses including: Upper Respiratory Tract Acute sinusitis Acute rhinitis Common Cold and Flu Acute tonsillitis Respiratory System Acute bronchitis Bronchial asthma (Most effective in children and uncomplicated conditions.) Eye Disorders Acute conjunctivitis Central Retinitis Myopia (in children) Cataracts (without complications) Mouth Disorders Toothache Post Extraction Pain Gingivitis Acute and Chronic Pharyngitis Gastrointestinal Disorders Spasms of esophagus Hiccough Gastroptosis Acute and Chronic Gastritis Gastric Hyperacidity Chronic Duodenal Ulcer (pain relief) Acute Duodenal Ulcer (without complications) Acute and Chronic Colitis Acute Bacillary Dysentery Constipation Diarrhea Neurologic and Musculoskeletal Disorders Headache and Migraine Trigeminal Neuralgias Facial Palsy (early stage, i.e., within 3-6 months) Pareses Following a Stroke Peripheral Neuropathies Sequelae of Poliomyelitis (early stage, i.e., within 6 months) Menieres Disease Neurogenic Bladder Dysfunction Nocturnal Enuresis (bedwetting) Intercostal Neuralgia Cervicobrachial Syndrome Frozen Shoulder Tennis Elbow Sciatica Low Back Pain Osteoarthritis Carpal Tunnel Syndrome Back and Knee Pain Fibromyalgia Chronic Fatigue Sports Injuries and Pains Reproductive & Gynecological Conditions Premenstrual Syndrome Dysmenorrhea (menstrual cramps) Spotting and Excessive Bleeding Amenorrhea (Loss of Menstrual Period) Impotence Infertility Incontinence Prostatis Mental Emotional Problems Stress Anxiety Depression Insomnia The World Health Organization Interregional Seminar compiled the above list of illnesses that may benefit from Acupuncture treatment