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4 HER2-CAR-T cell in human solid tumor therapy In vitro , HER2-CAR-T cells exhibit robust targeted killing activity against a variety of solid tumors, including ovarian cancer ( In a clinical trial using third-generation HER2-CAR-T cells to treat a patient with metastatic colon cancer exhibiting HER2 overexpression, the patient succumbed 5 days post-treatment

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