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p16 ink4a is a senescence biomarker that induces cellular senescence through binding of CDK4 and CDK6, which prevents the downstream inhibition of the cell-cycle repressor retinoblastoma-associated protein [4, 45, 46]

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The physical shearing force can tear apart the delicate amino acid chains

After phosphorylation on residue Y705, p-STAT3 translocates to the nucleus to interact with specific regions, contributing to the transcription of target genes [64]