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The two compounds engage distinct but complementary receptor systems: Ipamorelin: Pentapeptide ghrelin/GHS receptor agonist selective for GH release without significant ACTH, cortisol, or prolactin elevation CJC-1295: GHRH analogue acting at the GHRH receptor on pituitary somatotrophs Combined research: Studies of pulsatile GH release frequently pair both compounds to examine synergistic effects across the two receptor pathways Bangkok Peptides supplies Ipamorelin individually as a 10mg vial and also stocks the pre-blended CJC-1295 / Ipamorelin combination for researchers using both compounds together

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Michelet F, Gueguen R, Leroy P, Wellman M, Nicolas A, Siest G