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Clinical rheumatology

36 Overall, treatment should be individualised according to the type of fistula, degree of rectal inflammation, and severity of symptoms

One published review article compiled decades of research in BioMed Research International that support its regenerative benefits

For example, curcumin has been evaluated in Phase II clinical studies in pancreatic cancer and colorectal cancer patients, where oral doses up to 8 g/day demonstrated acceptable safety but limited systemic exposure, highlighting pharmacokinetic challenges