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If you dont have enough B12, you might suffer from anemia, irritability, fatigue, muscle weakness, and numbness

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Additionally, dosing at 20 mg/kg body weight or greater resulted in mild to severe fundic lesions on ophthalmologic examination (change in color of the fundus, central or generalized retinal degeneration), abnormal electroretinograms (including blindness), and diffuse light microscopic changes in the retina

Especially from poor diet, smoking, certain medical conditions, or high physical stress