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Effect of increasing doses of recombinant human insulin-like growth factor-I on glucose, lipid, and leucine metabolism in man

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Ipamorelin activates GHS-R1a through Gq-coupled phospholipase C, increasing IP3 and intracellular calcium, which triggers vesicle fusion and exocytosis

Key mechanistic observations from laboratory studies: G-actin sequestration: TB-500 binds monomeric G-actin, regulating the pool available for filament polymerization

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