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Conversely, within acidic tumor microenvironments, upregulated PPAR fuels cancer cell proliferation and invasion by enhancing FAO and lipid droplet (LD) accumulation, thereby supporting the energy demands of acid-adapted CRC cells (95)

Preoperatively, the radiological appearance of the lesion showed a cystic, partially enhancing, hemorrhagic mass that could be indicative of several tumor types, including ependymoma, melanoma, or MS

Thus, we measured TrB1-3 distribution in B cell-specific Gclc -deficient mice and found that TrB1 were increased in Gclc -deficient mice compared to controls (Supplementary Fig

Hence, we can conclude that these actions may contribute to MTX-induced hepatotoxicity