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J Clin Endocrinol Metab 85 : 16861694 Rose DR and Clemmons DR (2002) Growth hormone receptor antagonist improves insulin resistance in acromegaly

However, full HGH also increases IGF-1, which affects muscle growth, organ size, and insulin resistance

For Canadian researchers, the practical takeaways: AOD-9604 isolates lipolytic activity without engaging GH receptors or affecting IGF-1 Tesamorelin activates the full GH axis through pituitary release of endogenous GH Both have substantive published research bases with different shapes Choice depends on whether isolated vs full-axis GH biology effects are the research goal Same quality framework Janoshik third-party testing applies to both For continued reading, see What Is AOD-9604

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