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Bmal1 regulates circadian expression of cytochrome P450 3a11 and drug metabolism in mice

A 50% toxicity rate was reached at 0.94mmol/l in HepG2 and 0.68mmol/l in HepG2 ATP7B-KO cells

Glutathione ethyl ester reverses the deleterious effects of fentanyl on ventilation and arterial blood-gas chemistry while prolonging fentanyl-induced analgesia

Although causal relationships remain to be fully established, these mechanisms provide a preliminary basis for exploring HPA-axis modulation as a therapeutic approach (Fig