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The appropriate functionalisation of these inhibitors such as C-6 and C-7 hydroxyl groups of the isoflavone skeleton, 4-functionalisation thiophene-2-carbaldehyde thiosemicarbazone with a methoxyacetyl group and the aldehyde group and methoxy group in C4 of benzaldehyde derivatives may be improved the inhibitory activity of these inhibitors

This finding is very interesting and can open new insights to counteract AFB1 toxicity in broilers fed contaminated diets, by using CURC as a NOX inhibitor

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These proteins are likely regulated by METTL3 during MASLD, and GO/ KEGG analyses identified associated terms indicative of METTL3 regulation