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spermidine from food sources including nuts, wheat germ, and soybeans has a good bioavailability (Madeo et al., 2018)

Zeng B, Ge C, Li R, Zhang Z, Fu Q, Li Z, et al

2023 Feb 8;24(4):3418

& Zhang, Y

The action of estradiol is primarily directed by interaction with the estrogen receptor (ER) nuclear receptors (alpha and beta) in peripheral target tissues further modulated via feedback by GH and IGF-1 (Veldhuis et al., 2006)