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[DOI] [PMC free article] [PubMed] [Google Scholar] 40.McGuire L., Heffner K., Glaser R., Needleman B., Malarkey W., Dickinson S., Lemeshow S., Cook C., Muscarella P., Melvin W.S., et al

CD46 is a membrane protein which known to bind and inactivate complement C3b and C4b (Cattaneo)

On this note, a study of Pakistani patients with coronary heart disease and Type II diabetes found that the C allele was significantly associated with markers of oxidative stress and damage to arterial lining (vascular endothelial dysfunction)

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But whenever Sinclair brings up senolytics, he usually mentions both fisetin and quercetin, both of which are potent anti-inflammatory plant-based compounds (polyphenols) that significantly reduce senescent cells in preclinical studies