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For example, in patients with renal insufficiency, high dose IVC may lead to kidney stone formation or acute oxalate nephropathy [65, 264], while a red cell glucose-6-phosphate dehydrogenase deficiency (G6PD) has been linked to cases of hemolytic anemia [66, 265] following high dose IVC, sugesting both of these condition should be screened for prior to high dose IVC administration

Ann Med 57(1):2559122 Jomova K et al (2023) Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging