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MOTS-C 20mg MOTS-C (Mitochondrial open reading frame of the 12S rRNA-c) is a peptide encoded in mitochondrial DNA

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The incidence of adverse experiences described in the Table below are based on data from a short-term clinical trial in vitamin B12 deficient patients in hematologic remission receiving Nascobal (Cyanocobalamin, USP) Gel for Intranasal Administration (N=24) and intramuscular vitamin B12 (N=25)

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Future efforts in the LCINS space include identifying a population with elevated germline and/or exposure-mediated risk to prioritize for LDCT screening (for example, individuals carrying large-effect rare variants associated with familial EGFR -mutant lung cancer), with studies already under way (such as NCT05587439 and NCT05265429)