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It is especially critical in the detoxification of harmful substances and the neutralization of free radicals, making it one of the primary defense mechanisms against oxidative stress

Back to Journals Diabetes, Metabolic Syndrome and Obesity Volume 18 Marmelosin Protects Against Metabolic Disturbances in High-Fat Diet and Streptozotocin-Induced Diabetes Authors Alenezi SK , Alharbi KS , Alsahli TG, ALQahtani R, Afzal M , Sharma KK, Sayyed N Received 9 October 2025 Accepted for publication 20 November 2025 Published 30 December 2025 Volume 2025:18 Pages 47694785 DOI Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Rebecca Baqiyyah Conway Sattam Khulaif Alenezi, 1 Khalid S Alharbi, 1 Tariq G Alsahli, 2 Reem ALQahtani, 3 Muhammad Afzal, 4 Krishana Kumar Sharma, 5 Nadeem Sayyed 6 1 Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraydah, Al Qassim, 51452, Saudi Arabia

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Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding