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As a result, aging is considered a key predictive marker for the development of PDD (Aarsland et al., 2017, 2021)

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Human pancreatic stellate cell (hPSC) culture and treatments HPSCs (Fenghui Biotechnology Co., Ltd., Changsha, China) were cultured in RPMI 1640 medium (Gibco) with glucose (5.5 mmol/L glucose) supplemented with 10% FBS (Gibco) in an incubator with 5% CO2 at 37 C

Curcumin increases intracellular ROS levels and a treatment with an antioxidant partially reverses the anti-proliferative effects of curcumin Since many curcumin-binding candidates identified in this study (CBR1/3, GSTP1/O1, NQO1/2, AKR1C1/D1, PRDX1, GLO1, and ADH1A shown in Table 1) belong to the enzymes involved in the metabolism of ROS and oxidative-stress products (such as Reactive Carbonyl Species, RCS) 18 , and because curcumin inhibits the enzymatic activity of CBR1 19 , GSTP1 20 , NQO1 21 , and GLO1 22 in vitro , we speculated that the treatment with curcumin up-regulates intracellular ROS levels in CML-derived leukemic cells

From the above-mentioned studies it is clearly showed that temperature is an important factor affecting the composition and diversity of the GM