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1 Introduction Lumbar degenerative disc disease (LDDD), an age-associated disease characterized by severe back pain and disability (Ohtori et al., 2015), is highly prevalent across the world

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The genes most commonly amplified in bladder cancer include AHR, BCL2L1, CCND1, CCNE1, E2F3, EGFR, ERBB2, FGFR3, GATA3, KRAS, MDM2, MYCL1, PPARG, PVRL4, SOX4, TERT, YWHAZ , and ZNF703 , whereas the most commonly deleted genes are TP53, FGFR3, KDM6A, STAG2, CDKN2A , and RAD51B [106]