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This assumption is further strengthened after observing an increased expression of pro-apoptotic proteins Bim and Puma , the downstream effector of the Bcl-2 family, in the tumor samples having GG- rather than AA-genotype

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Autophagy 14 , 199206 (2018)

However, certain conditions such as poor diet, lifestyle, and environmental factors such as pollution and exposure to radiation may increase free radicals in the body

injections of vehicle or L2-Cmu (20 mg/kg) once per week and were monitored for interim survival to 24 mo of age ( n = 2438 per group) and sacrificed for blood, tissue, and histopathologic analysis