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This work predates modern trial registration, pre-specified endpoints, and publication-bias safeguards

Most human clinical trials that report measurable changes run for at least several weeks and often three months or longer

However, the inhibition of COX-2 activity can change its adhesion ability

Establishing a minimal key set of proteins using recursive feature elimination To gain insights into the biological patterns driving skin aging and improve on the interpretability of our predictive model, we aimed to identify a minimal set of key proteins that retained strong predictive power for age estimation