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6 Conclusions A new form of cell death, termed ferroptosis, was initially characterized in 2012 as distinct from apoptosis and autophagy

E6 has been shown to decrease levels of the main intracellular antioxidants glutathione (GSH) and catalase (CAT), along with their enzymatic activities, resulting in increased ROS production and DNA damage [226]

More recently, noninvasive imaging techniques have enabled the detection of these proteins directly within the living brain, marking a major milestone in the field

[ref] Not only is B6 important in dopamine production, but it is also important in the creation of glutathione (an antioxidant) in the brain.[ref] Parkinsons patients on L-DOPA also often have low or deficient B6 levels.[ref] Related article : Parkinsons disease and genetic susceptibility Chronic inflammation: Inflammatory conditions, including rheumatoid arthritis, IBD, diabetes, cancer, and deep vein thrombosis, are all associated with low vitamin B6 levels.[ref] While inflammatory conditions are linked to low vitamin B6 levels, it may be (at least partly) because systemic inflammation decreases the bodys P5P levels, and dietary intake isnt sufficient to meet the increased need.[ref] Related article: Chronic inflammation and personalized solutions Asthma and COPD: A recent study showed that higher vitamin B6 intake correlates with higher FEV1 levels (lung function test) in CoPD