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doi: 10.2147/IJN.S454445 131 NanYChenMWuWHuangRSunWLuQet al

Dysregulation of PI3K/Akt signaling underlies insulin resistance in PCOS

This is different from comorbidities affecting established RA patients (e.g., cardiovascular disease, infection, lymphoma, osteoporosis), which occur at higher rates than the general population and have a significant impact in the prognosis of the disease (see below) (2, 163)