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doi: 10.1165/rcmb.2014-0289OC 22 PiedrahitaJAOetamaBBennettGDvan WaesJKamenBARichardsonJet al

A novel, orally bioavailable, small-molecule inhibitor of PCSK9 with significant cholesterol-lowering properties in vivo

The compound activates HGF/c-Met signaling in hippocampal and cortical regions at picomolar to nanomolar concentrations, suggesting efficient distribution to the brain regions most relevant to learning and memory