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1994 Nov;43(3):351-9. [PMID: 7966443]

Bermejo P, Martin-Aragon S, Benedi J et al

This mechanism also acts as a vital "on/off" switch for cellular signaling, modulating enzyme activity and controlling how DNA binds to transcription factors during an immune response

Figure 1 Furthermore, SAM serves as a methyl donor, methylating DNA and proteins, including histones (Zade et al., 2023), which in turn influences epigenetic regulation, and gene expression ( Figure 1 )