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Biomed Prev Nutr 3(3):227232 Li R, Guo LX, Li Y, Chang WQ, Liu JQ, Liu LF, Xin GZ (2017) Dose-response characteristics of Clematis triterpenoid saponins and clematichinenoside AR in rheumatoid arthritis rats by liquid chromatography/mass spectrometry-based serum and urine metabolomics