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the substitution T161A severely impairs DOR desensitization measured on GIRK channels (Lowe et al., 2002)

Therefore, we need to explore the resistance mechanism of sorafenib and novel treatments against HCC, such as c-Met and downstream signaling pathway inhibitors (Hu et al., 2017)

Additionally, anxiety and stress trigger SNS hyperactivity, increasing renin release and angiotensin II, which promote renal vasoconstriction and tubulointerstitial damage (Wang and Dong, 2016) while elevated norepinephrine levels under mental distress accelerating kidney function decline (Tidgren and Hjemdahl, 1989)