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Clinical Cancer Research 25(23):6887-6889, 2019

Regulation of Met metabolism in the liver In the liver, when the consumption of Met exceeds its average dietary intake, de novo synthesis of Met occurs via the transfer of a methyl group from methylene-THF first by methylene-THF reductase (MTHFR) and then by Met synthase (MS) to Hcy to form Met to make up the difference (Figure 2)