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After exposure to immunostimulants, there is an enhancement of cytokines in the fetal brain and maternal serum, amniotic fluid and placenta (Urakubo et al., 2001)

Overexpression of MMPs can result to excessive ECM breakdown, contributing to the pathogenesis of various respiratory diseases such as chronic obstructive pulmonary disease (COPD), asthma, acute respiratory distress syndrome (ARDS) and pulmonary fibrosis [37,38,39,40]

Current perspectives suggest a bidirectional interaction between peripheral immune activation and central inflammation: peripheral inflammation can enhance intracerebral inflammation via the BBB or vagal nerve pathways, while central inflammation can, in turn, stimulate the peripheral immune system (Shin et al., 2022

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This included the CIII subunit core protein 2 and CIV subunit MTCO1, indicating that GSH-deficiency altered protein expression independently of the overall activity of CIII and CIV