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Therefore, it appears that long-term supplementation is a required before effects become apparent

Indeed, one alternative hypothesis, that CVS is associated with dominantly-inherited brain neurotransmitter receptor genes, was evaluated in parallel and found to have a far fewer (and highly statistically significant) Key and total Qualifying variants among the gene lists

Total symptom score decreased significantly compared to placebo across treatment groups of all doses 600-1800 mg/d oral ALA, yet there was a dose-dependent increase in nausea, vomiting, and vertigo, and therefore the lowest dose of oral ALA (600 mg/d) is recommended

4 : 237247 Pettegrew JW, Woessner DE, Minshew NJ