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Tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl), a drug previously known to inhibit cancer cell proliferation and increase vulnerability to other cytotoxic agents, has been shown to interfere with glutamine metabolism through inhibition of IDH1/2 and slowing of the TCA cycle [99]

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Then, a grid was generated by taking the standard ligand bound to the co-crystallized protein as the center, and the grid coordinates were noted

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