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10.1038/s41598-020-67532-2 53 WoodT

Materials and methods Ethic statements The animal studies were carried out in strict accordance with the Detailed Rules for the Administration of Animal Experiments for Medical Research Purposes issued by the Ministry of Health of the Peoples Republic of China and were approved by the Animal Experiment Administration Committee of The Fourth Military Medical University

IB kinase /nuclear factor-B-essential modulator (IKK/NEMO) facilitates RhoA GTPase activation, which, in turn, activates Rho-associated KINASE (ROCK) to phosphorylate IKK in response to transforming growth factor (TGF)-1

In preclinical models, it improved functional, structural, and biomechanical outcomes across muscle, tendon, ligament, and bone injury models

There has been little focus on the development of high-throughput, in vitro assays to model the vessels that are insensitive to VEGF inhibition