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(eds Lambers, H., Van Der Plas, H

Ammonia-mediated astrocyte activation exacerbates brain injury in MMAemia, as demonstrated by elevated glial fibrillary acidic protein expression in cortical, hippocampal, and striatal regions, along with increased TNF- and IL-1 levels in murine models receiving combined ammonia and MMA treatment (Gabbi et al

A likely explanation is that it supports energy production, which the brain needs

Notably, sulforaphane treatment was found to enhance STAT1 phosphorylation, suggesting its potential therapeutic mechanism [33]

This increase is likely linked to the consumption of a high-energy diet, which appears to promote the mRNA expression of the FABP3 and APOB genes, thereby facilitating the increased IMF deposition in muscle tissues [112]