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Researchers may examine inflammatory markers and cytokine-related pathways in controlled experimental models

Based on the above limitations and perspectives, it is beneficial to address the question of how metabolic abnormalities develop in AAD in the future, thus determining which pathways are ideal therapeutic targets

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These postmortem results, along with those from the current and our previous study that highlighted a considerable number of differentially serum expressed amino acids between cases and controlsespecially in malessupport the idea that PD is a heterogeneous systemic disease that disrupts metabolic homeostasis across both central and peripheral organs (Costa et al., 2023)

QTL significance was determined using logarithm of odds (LOD) scores, with a threshold of 7