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Specifically, the surface of the gastrointestinal tract is covered by a mucous layer about 50450 m thick, with a pore size of about 501800 nm and a negative charge, forming a complex physicochemical barrier ( Chitosan can enhance the transepithelial permeability of anticancer drugs by temporarily opening tight junctions between epithelial cells ( The carboxyl group on the alginate molecular chain can electrostatically interact with the positively charged protein in the colon mucosa to form a hydrophilic adsorption layer (Figure 2B)

SP received a grant (INV-059675) from Bill and Melinda Gates Foundation (BMGF) that supported the Commission including salaries for SL, AMM, RB, NC, CG-W, VO, and YW, and travel support for Commission meetings for SHA, PSS, SP, PW, MNM, CC, BC, SL, AMM, MB, RB, NC, CG-W, VO, and YW

Expectedly, depletion of cystine or inhibition of the Xc- antiporter using synthetic small molecule inhibitors including erastin, sulfasalazine, sorafenib and even excess of glutamate triggered cystine depletion, decreased GSH level and reduced GPX4 activity, culminating in ferroptosis induction

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