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(September 2005)

Inflammasomes and autoimmune and rheumatic diseases: a comprehensive review

However, high-dose L-carnitine therapy provides a massive amount of fuel for gut bacteria, causing them to produce more TMA than the livers FMO3 enzymes can process at one time [12] [13]

Funding This project was financed by the National Natural Science Foundation of China (grant number 31871169 to YT, 81600040 to A-PW), Innovation guidance project of Hu Nan (grant number 2018SK51606 to S-XG, 2018SK51703 to NL), the province Natural Science Foundation of Hu Nan (grant number 2020JJ8032 to YT, 2021JJ30601 to A-PW)

Material and methods Cell culture Primary neurons were obtained from the triple transgenic mouse model of AD (3xTg-AD) with human APP (SWE), PS1 (M146V), and Tau (P301L) transgenes [18] in three different age ranges: young (26 months), middle (811 months) and old (1728 months), around the median lifespan