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Various glutaminase inhibitors have been developed and characterized, including allosteric inhibitors of the 968 class and the BPTES series of compounds [19, 21, 28, 35-37]

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The oil-in-water method is suitable for water-soluble drugs, involving the dissolution of drugs and organic materials in the oil phase, followed by conversion to an aqueous phase through emulsification or ultrasound, resulting in the formation of nanoparticles with good dispersibility and stability 119

Compounds Metro-P3 , MF-01 , MF-02 and MF-03 were administered at 10 mg kg 1 perorally (by using a peroral gavage