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Growth of cancerous cells, metabolite synthesis, tissue disturbances, and involvement of normal cells in the disease interfere with normal biological functioning and cause pain, organ failure, and cancer-related symptoms 59

Li Y, Pollock CA, Saad S

They are also beneficial for those with B12 deficiency, vegetarians, vegans, and individuals with certain medical conditions that affect B12 absorption

This is due to orange oils hydroxylated polymethoxyflavones (a group of flavonoid compounds mainly found in citrus plants) that are associated with modulating key signaling proteins related to cell proliferation and apoptosis

Primer sequences for qRT-PCR are shown in Supplementary Table S2